Student Nurses Are Writing Their Final Exam on Diuretic Therapy

Student nurses are writing their final exam on diuretic therapy. There are asked to identify the mechanism of action of chlorothiazide (Diuril) . Which is the correct response?

A) Act on the early distal tubule to block the reabsorption of sodium, chloride, and water.
B) Inhibit reasborption of bicarbonate ion in proximal tubule.
C) Act on the ascending limb of the loop of Henle to block the reabsorption of sodium, chloride, and water
D) Creates an osmotic force that pulls water into the nephron and increases the excretion of nearly all electrolytes.