Which Statements Regarding the 4 Phases of Clinical Research of Drug

Which statements regarding the 4 phases of clinical research of drug development are true?

A) 90 % of drugs do not proceed past the 2nd phase because they are found to be ineffective.
B) In the second phase, clients with the disease or condition that the drug will treat are given the drug to determine doses and side effects
C) The clinical stage of research involves extensive testing on animals in the laboratory to determine if the drug will cause harm to humans.
D) Absorption, metabolism and excretion of a drug is determined in the first phase of clinical trials
E) A clinical trial will not be suspended until 2000-3000 people with the affected disease or condition have trialled the drug .