A client has been started on diltiazem (Cardizem) ,a susbstrate of the cytochrome CYP3A4 isoenzyme system.The client also takes phenobarbital,an inducer of the CYP3A4 isoenzyme system,for seizures.What does the nurse recognize about diltiazem?
A) It will not be able to cross the blood brain barrier (BBB) .
B) It will be metabolized by the kidneys.
C) It might be inactivated at a faster rate than normal.
D) It might be excreted at a slower rate.
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