Bromine Is a Dense,deep Red-Brown Liquid Obtained by the Oxidation $\alpha$

Bromine is a dense,deep red-brown liquid obtained by the oxidation of bromide ion in seawater.Bromine is very toxic.Which of the following reactions of bromine with organic materials would be least likely in a biological system (would not occur) ?

A) Addition to non-aromatic carbon-carbon double bonds (e.g.,in fatty acids)
B) Electrophillic aromatic substitution of very activated aromatic rings (e.g.,in tyrosine,a phenol)
C) Oxidation of aldoses to aldonic acids (e.g.,CHO to CO₂
D) ( $\alpha$ -bromination of fatty acids (e.g.,RCH₂CO₂H $\rightarrow$ RCHBrCO₂H) )
E) None of these reactions could occur in living systems.