In which electrophilic aromatic substitution reaction can unintended poly-substitution (i.e.,disubstitution,trisubstitution,etc.)be a problem?

Question

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Friedel-Crafts alkylation can result in unintended poly-substitution because the alkyl group is a strong activator and can undergo multiple substitutions. This can lead to a mixture of different products with varying degrees of substitution, making it difficult to isolate the desired product. The other reactions listed are less likely to result in unintended poly-substitution.

In Which Electrophilic Aromatic Substitution Reaction Can Unintended Poly-Substitution (I