The principal mechanism of action of phenytoin (Dilantin) in treating status seizures is the:
A) blocking of GABA receptor sites to prevent further cellular activity in the CNS.
B) influx of calcium ions through calcium channels to enhance depolarization.
C) blocking of acetylcholine receptor sites at the neuromuscular junction to prevent convulsions.
D) prevention of sodium ions entering the cell by closing sodium channels.

Question

Quizplus · Accepted Answer

Phenytoin works by binding to the inactive state of voltage-gated sodium channels and slowing their recovery from inactivation. This reduces the ability of neurons to generate repetitive action potentials, which are necessary for the sustained activity seen in status seizures. By preventing sodium ions from entering the cell, phenytoin reduces the excitability of neurons and helps stop the seizure activity.

The Principal Mechanism of Action of Phenytoin (Dilantin) in Treating