Loop diuretics achieve their therapeutic effects by:
A) decreasing the absorption of sodium at the glomerulus.
B) decreasing the reabsorption of sodium at the ascending loop of Henle.
C) enhancing reabsorption throughout the loop of Henle.
D) increasing the reabsorption of sodium at the ascending loop of Henle.

Question

Quizplus · Accepted Answer

Loop diuretics, such as furosemide, work by inhibiting the sodium-potassium-chloride cotransporter in the thick ascending limb of the loop of Henle. By doing so, they decrease the reabsorption of sodium, chloride, and water, resulting in increased urine output and decreased volume overload.

Loop Diuretics Achieve Their Therapeutic Effects By