Class II promoters can be identified using ChIP-chip analysis with an anti-TAF1 antibody.

Question

Quizplus · Accepted Answer

TAF1 (TATA-binding protein-associated factor 1) is a component of the general transcription factor IID (TFIID) complex, which binds to the TATA box and initiates transcription. Class II promoters typically do not have a TATA box, but they do have other cis-regulatory elements that recruit TFIID. ChIP-chip analysis with an anti-TAF1 antibody can identify the genomic regions bound by TFIID, and thus infer the location of Class II promoters.

Class II Promoters Can Be Identified Using ChIP-Chip Analysis with an Anti-TAF1