Amber mutations are mutations that create termination codons in the middle of an mRNA causing premature translation termination.

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This statement is true. Amber mutations are a type of nonsense mutation that result in the insertion of a premature stop codon (UAG) into the middle of an mRNA sequence, leading to early termination of translation before the full protein can be synthesized.

Amber Mutations Are Mutations That Create Termination Codons in the Middle