Which of the following techniques would be most useful in testing the ability of the core RNA polymerase to bind to the promoter?

Question

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DNAse footprinting is a technique that can be used to identify the specific DNA sequence that is bound by a protein. In this case, the core RNA polymerase can be incubated with a segment of DNA that includes the promoter region, and then treated with DNAse to cut the DNA at unprotected regions. The resulting fragments can be separated by gel electrophoresis and compared to a control sample without the RNA polymerase, allowing for identification of the protected region where the RNA polymerase is bound. This technique would thus be most useful in testing the ability of the core RNA polymerase to bind to the promoter.

Which of the Following Techniques Would Be Most Useful in Testing