The adrenal medulla synthesizes catecholamines.The first enzyme in the catecholamine synthesis pathway,tyrosine hydroxylase,is stimulated by:

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Tyrosine hydroxylase, the first enzyme in the catecholamine synthesis pathway, is stimulated by acetylcholine. This occurs in the adrenal medulla, where acetylcholine acts as a neurotransmitter to initiate the synthesis of catecholamines such as epinephrine and norepinephrine.

The Adrenal Medulla Synthesizes Catecholamines