Cortisol can bind to both the glucocorticoid receptor and the mineralocorticoid receptor.In the cells of the distal nephron,cortisol is prevented from binding to the mineralocorticoid receptor by:

Question

Quizplus · Accepted Answer

Cortisol is prevented from binding to the mineralocorticoid receptor in the cells of the distal nephron by being converted to cortisone, which has a much lower affinity for the mineralocorticoid receptor. This conversion is catalyzed by the enzyme 11β-hydroxysteroid dehydrogenase type 2.

Cortisol Can Bind to Both the Glucocorticoid Receptor and the Mineralocorticoid