Although pregnant women do not typically exhibit hyperthyroidism,maternal total T₄ levels increase during pregnancy.This benign increase in total T₄ is due to:

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During pregnancy, there is an increase in estrogen levels that stimulate the liver to produce higher levels of thyroid hormone-binding globulin (TBG). TBG is a protein that binds to thyroid hormones and transports them in the bloodstream. This increase in TBG leads to an increase in total T₄ levels in the bloodstream, but typically not an increase in active thyroid hormone (free T4 and free T3). This increase in TBG levels is a benign and normal adaptation during pregnancy.

Although Pregnant Women Do Not Typically Exhibit Hyperthyroidism,maternal Total T4

Although Pregnant Women Do Not Typically Exhibit Hyperthyroidism,maternal Total T₄