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Malignant Hyperthermia Is a Hereditary Disorder That Can Increase Surgical

Question 4

Multiple Choice

Malignant hyperthermia is a hereditary disorder that can increase surgical risk because temperature may be elevated during certain types of anesthesia.The cause of the increased temperature is an increase in cytosolic Ca++ level as a result of an anesthetic-induced:


A) Increase in Ca++ release from the SR,as a result of a mutation in the ryanodine receptor.
B) Decrease in Ca++ uptake by the SR,as a result of a mutation in SERCA.
C) Increase in frequency of the rupturing of skeletal muscle fibers.
D) Decrease in Ca++ extrusion,as a result of hyperphosphorylation of the plasmalemmal Ca++ pump.
E) Increase in Ca++ influx,as a result of a mutation in N-type Ca++ channels.

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