Most Anticancer Drugs Exert Severe and Potentially Toxic Side Effects

Most anticancer drugs exert severe and potentially toxic side effects because:

A) these drugs have a high therapeutic index (TI) .
B) most of these drugs are not approved by the Food and Drug Administration (FDA) .
C) most of these drugs do not discriminate between healthy tissues and cancerous cells.
D) these drugs all have extremely long half-lives,and tend to accumulate in the body for an extended period.
E) the threshold dose of these drugs is typically much higher than in other drugs.