Several COX-2 selective inhibitors such as rofecoxib (Vioxx)and valdecoxib (Bextra)have been taken off the market because these drugs can cause side effects such as:

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COX-2 selective inhibitors such as rofecoxib and valdecoxib have been taken off the market due to the increased risk of heart attack and stroke associated with their use. Liver failure, brain tumors, kidney failure, and skeletal muscle inflammation and myopathy are not common side effects of these drugs.

Several COX-2 Selective Inhibitors Such as Rofecoxib (Vioxx)and Valdecoxib (Bextra)have