The ______ effect occurs when drugs are initially transported to the liver where a significant amount of the drug may be metabolized and destroyed before the drug reaches its primary site of action.

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The first-pass effect, also known as presystemic metabolism, occurs when a significant amount of a drug is metabolized by the liver before it reaches its target site of action. This can result in a lower bioavailability of the drug, meaning that less of the drug is available to produce its desired effects.

The ______ Effect Occurs When Drugs Are Initially Transported to the Liver