All of the Following Statements About Local Anesthesia Are True

All of the following statements about local anesthesia are true EXCEPT for one. Which one is the EXCEPTION?

A) Hemostasis is only achieved when the vasoconstrictor is deposited into the area of bleeding
B) Maximum dosages of all drugs administered by injection should be calculated by body weight
C) Children can tolerate adult doses of local anesthetics because of their faster metabolism, and overdose is of little concern
D) The possible causes of decreased anesthetic effect include edema, pH, and vascularity
E) Overdose reactions are dose related; allergic reactions are not dose related