A big limitation of anti-HIV therapy, especially in third world countries, is the

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The cost of anti-HIV therapy is a significant limitation, particularly in third world countries with limited resources. Many people cannot afford the medications, making it challenging to distribute and administer the medication. Therefore, D is the best choice. While the other options may contribute to the issue, the central problem is the cost.

A Big Limitation of Anti-HIV Therapy, Especially in Third World