The development of lymph node enlargement in the region of a skin ulcer after a tick or insect bite or handling of a wild animal suggests

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The development of lymph node enlargement in the region of a skin ulcer after a tick or insect bite or handling of a wild animal suggests tularemia, also known as rabbit fever. Tularemia is caused by the bacterium Francisella tularensis, which can be transmitted to humans by ticks, mosquitoes, and other insects or by direct contact with infected animals. Symptoms may include fever, headache, muscle aches, and swollen lymph nodes. Infection can be treated with antibiotics, but prompt diagnosis and treatment are important to prevent complications. Brucellosis is typically associated with contact with infected animals or consumption of contaminated dairy products, and may cause fever, joint pain, and other symptoms. Endocarditis is a serious infection of the heart valves that typically develops slowly over weeks to months and may cause fever, fatigue, shortness of breath, and other symptoms. Septicemia is a severe and potentially life-threatening bloodstream infection that can be caused by a wide range of bacteria, viruses, and other pathogens.

The Development of Lymph Node Enlargement in the Region of a Skin