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Why Would a Person Who Has AIDS Be More Susceptible

Question 65

Multiple Choice

Why would a person who has AIDS be more susceptible to the bacterium that causes tuberculosis?


A) HIV (which causes AIDS) directly infects and destroys CD8+ T-cells. These are the cells that would actively destroy the bacterium that causes tuberculosis.
B) HIV (which causes AIDS) directly inhibits the production of interferons. Interferons have a strong natural antibacterial activity, and are necessary for elimination of the bacterium that causes tuberculosis.
C) HIV (which causes AIDS) destroys CD4+ helper T-cells. These are the cells that help activate and increase the bacteria-destroying capabilities of macrophages. Activated macrophages are required to help clear out the bacterium that causes tuberculosis, so without the CD4+ T-cells, we won't have activated macrophages.
D) HIV (which causes AIDS) directly infects and destroys antibody-producing B-cells. Without the ability to produce antibodies, we can't opsonize and ingest/destroy the bacterium that causes tuberculosis.

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