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A New Drug Has Been Discovered That Inhibits the Activity

Question 61

Multiple Choice

A new drug has been discovered that inhibits the activity of DNA polymerase III. Is this drug useful for human beings?


A) Yes-it will inhibit the synthesis of DNA in bacteria, serving as a useful antibiotic.
B) No-DNA polymerase III is highly conserved, and it's likely that an inhibitor of the bacterial version would also inhibit the human version, harming our own cell's DNA synthesis.
C) Yes-DNA polymerase III is essential for filling in the gaps between Okazaki fragments in bacterial DNA synthesis. Without its function, bacterial DNA synthesis will stop.
D) No-there are redundancy mechanisms and polymerases in place (i.e. DNA polymerase I) that could fill in for the impaired DNA polymerase III.

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