Exhibit 29-3
Use the data below to answer the following question(s).
Mevalonate is an important intermediate in the biosynthesis of cholesterol.This six-carbon compound can be formed from acetyl CoA utilizing two separate pathways.The most significant one involves the intermediate β-hydroxy-β-methylglutaryl-CoA.
-Refer to Exhibit 29-3.In step 2 of the mevalonate biosynthesis,acetoacetyl CoA is converted into β-hydroxy-β-methylglutaryl-CoA.This reaction is analogous to:

Question

Exhibit 29-3
Use the data below to answer the following question(s).
Mevalonate is an important intermediate in the biosynthesis of cholesterol.This six-carbon compound can be formed from acetyl CoA utilizing two separate pathways.The most significant one involves the intermediate β-hydroxy-β-methylglutaryl-CoA. 
-Refer to Exhibit 29-3.In step 2 of the mevalonate biosynthesis,acetoacetyl CoA is converted into β-hydroxy-β-methylglutaryl-CoA.This reaction is analogous to:

Quizplus · Accepted Answer

The conversion of acetoacetyl CoA into β-hydroxy-β-methylglutaryl-CoA involves the addition of a hydroxyl group to a β-carbon next to a carbonyl, which is characteristic of an aldol reaction.

Exhibit 29-3 Use the Data Below to Answer the Following Question(s)