Which of the following will take place via nucleophilic acyl substitution?

Question

Quizplus · Accepted Answer

Nucleophilic acyl substitution involves a nucleophile attacking the carbonyl carbon of an acyl compound (such as an acid chloride or ester) and displacing the leaving group (usually a halide or a leaving group from the alcohol or thiol used to make the acyl compound). In this case, an ester can react with an amine (the nucleophile) to produce an amide, which is a type of acyl compound. The other options either do not involve a nucleophile (option D) or the reaction would not be classified as nucleophilic acyl substitution (options A and B involve the transformation of one type of acyl compound to another through a different mechanism).

Which of the Following Will Take Place Via Nucleophilic Acyl