What causes massive inflammation and necrosis in acute pancreatitis?

Question

Quizplus · Accepted Answer

The activation and spread of proteolytic enzymes is the primary pathophysiologic mechanism of acute pancreatitis. These enzymes, such as trypsin, amylase, and lipase, can digest pancreatic tissue and cause massive inflammation and necrosis. Thrombi and ischemia, infection by intestinal microbes, and immune complex reactions can contribute to the progression of acute pancreatitis, but they are not the primary cause of the inflammation and necrosis seen in the disease.

What Causes Massive Inflammation and Necrosis in Acute Pancreatitis