Which statement regarding changes in pharmacodynamics in the elderly is true?

Question

Quizplus · Accepted Answer

Altered receptor sensitivity in older adults can cause increased CNS sedation with benzodiazepines, opiates, and neuroleptics. This is due to changes in the number and sensitivity of receptors in the brain as a person ages. Elderly patients are also more likely to experience adverse effects at lower doses of these medications. Additionally, the statement in option B is not entirely accurate as elderly patients may experience increased sensitivity to the effects of diuretics, but they can also experience decreased sensitivity due to impaired renal function. Option C is also incorrect as elderly patients may be less responsive to beta-adrenergic blockers due to decreased cardiac output and impaired baroreceptor reflexes. Option D is also incorrect as elderly patients may be more susceptible to adverse effects at normal doses due to changes in pharmacokinetics and pharmacodynamics.

Which Statement Regarding Changes in Pharmacodynamics in the Elderly Is