Which Option Describes the Mechanism of Action of PIs

Which option describes the mechanism of action of PIs?

A) Bind to an active site used by viral protease enzymes so they cannot process viral precursors critical to the maturation of HIV virus
B) Bind to the active site of HIV reverse transcriptase and their antiviral activity is additive or synergistic with most other antiretrovirals
C) Convert to active compounds in the presence of host enzymes,becoming part of the DNA chain,where they interfere with DNA synthesis and viral replication through their inhibition of viral RNA
D) Compete with natural nucleotides in the host that would otherwise be incorporated into the newly synthesized DNA copies of the HIV virus;therefore,inhibit viral growth by terminating the virus' DNA chain