Which mechanisms of action accounts for a large portion of side effects when taking TCAs?

Question

Quizplus · Accepted Answer

TCAs have a variety of mechanism of actions including blocking neuronal reuptake of norepinephrine and serotonin at the presynaptic terminals, but a large portion of their side effects come from blocking histamine-1 and alpha-adrenergic receptors. This can result in sedation, weight gain, dry mouth, constipation, orthostatic hypotension, and blurred vision.

Which Mechanisms of Action Accounts for a Large Portion of Side