On-off syndrome is a complication typically appearing after 2 or more years of which type of Parkinson's disease medications?

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On-off syndrome is a complication that is typically seen in patients taking levodopa (also known as L-dopa) for 2 or more years. The syndrome is characterized by fluctuations in motor function that can occur unpredictably, with sudden switches between mobility and immobility. Patients may experience periods of the day where they are able to move and function normally (on periods), followed by periods where they experience severely reduced mobility and rigidity (off periods). This can have a significant impact on the patient's quality of life and may require adjustments to their medication regimen.

On-Off Syndrome Is a Complication Typically Appearing After 2 or More