Because calcium channel blockers undergo significant first-pass metabolism,which of the following responses would you expect to occur in a patient with cirrhosis who is taking a calcium channel blocker?

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First-pass metabolism occurs in the liver before drugs reach systemic circulation. Patients with cirrhosis may experience impaired liver function, which can impact drug metabolism and clearance. As calcium channel blockers undergo significant first-pass metabolism, their half-life may be altered in cirrhotic patients. This can lead to increased drug levels in the body and potential adverse effects. Therefore, careful monitoring and adjustment of the dosage may be required for these patients.

Because Calcium Channel Blockers Undergo Significant First-Pass Metabolism,which of the Following