What Is the Mechanism of Action of an Ophthalmic Topical

What is the mechanism of action of an ophthalmic topical anesthetic agent?

A) Acting at the systemic level,they block the effects of histamine release,thereby blunting its symptoms and decreasing the sensation of pain.
B) Acting locally,they block initiation and conduction of nerve impulses by decreasing the neuronal membrane's sensitivity to sodium ions,thereby decreasing the sensation of pain.
C) Acting at the cellular level,they inhibit dihydrofolate synthesis,thereby decreasing the sensation of pain.
D) Acting at the systemic level,they prevent the protein synthesis required for sodium ion transport,thereby decreasing the sensation of pain.