What advantage do COX-2 isomers possess that makes them more desirable than COX-1 isomers for the treatment of osteoarthritis?

Question

Quizplus · Accepted Answer

COX-2 isomers are released upon the initiation of inflammation, which makes them more desirable than COX-1 isomers for the treatment of osteoarthritis. Inflammation is a major contributor to the pain associated with osteoarthritis, and by targeting COX-2 specifically, drugs can be developed that reduce inflammation and pain without affecting other organs or bodily functions. COX-1, on the other hand, has important roles in protecting the stomach lining and regulating blood flow to the kidneys, which makes it less desirable as a target for osteoarthritis treatment.

What Advantage Do COX-2 Isomers Possess That Makes Them More