Medications to Prevent Migraine Headache Share All the Following Characteristics

Medications to prevent migraine headache share all the following characteristics EXCEPT

A) The prophylactic drugs of choice for migraine headache are beta-blockers.
B) All of these preparations are safe for use in pregnancy.
C) Migraine prophylaxis is indicated in the person who has frequent migraine headaches.
D) Opioids are used prophylactically for migraine headaches.
E) Both b and d are not true statements.