Thiazide diuretics have a major side effect: loss of potassium.

Question

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Thiazide diuretics work by increasing the excretion of sodium and water from the body, but they also decrease the excretion of potassium. This can lead to potassium depletion and potentially cause symptoms like muscle weakness, cramps, and arrhythmias. Therefore, patients taking thiazide diuretics may need to supplement with potassium or switch to a different type of diuretic that does not cause potassium loss.

Thiazide Diuretics Have a Major Side Effect: Loss of Potassium