Which of the Following Is NOT True of Histamine

Which of the following is NOT true of histamine?

A) It is a chemical found in body tissue that protects against environmental factors.
B) Its greatest concentration is found in the skin, gastrointestinal tract, and lungs.
C) Its principal action is vascular dilation and contraction of smooth muscles of the respiratory and gastrointestinal tract.
D) It is not a problem with most upper respiratory inflammatory diseases.
E) Sneezing, itching, watery eyes, and bronchoconstriction are often the result of histamine release.