Which of the Following Is NOT True of Treatment for COPD

Which of the following is NOT true of treatment for COPD?

A) Xanthine derivatives constrict smooth muscle, so sputum may be expectorated.
B) Epinephrine and ephedrine are used in the treatment of asthma and COPD to prevent bronchospasm.
C) Beta-adrenergic drugs such as Isuprel are used as respiratory agonists.
D) Beta₂ agonists are used to relieve ongoing asthmatic attacks.
E) Salmeterol is the preferred medication for prophylaxis of asthma.