Sally is a 16-year-old female with a urinary tract infection. She is healthy, afebrile, with no use of antibiotics in the previous 6 months and no drug allergies. An appropriate first-line antibiotic choice for her would be:

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Trimethoprim/sulfamethoxazole is a commonly used first-line antibiotic for uncomplicated urinary tract infections in young, healthy females without allergies to sulfa drugs. Azithromycin and ceftriaxone are not typically used as first-line options for urinary tract infections, and levofloxacin is reserved for more complicated infections or cases of resistance.

Sally Is a 16-Year-Old Female with a Urinary Tract Infection