In choosing a benzodiazepam to treat anxiety the prescriber needs to be aware of the possibility of dependence. The benzodiazepam with the greatest likelihood of rapidly developing dependence is:

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Alprazolam (Xanax) is known to have a high potential for dependence and withdrawal symptoms, particularly if taken for extended periods or in high doses. Chlordiazepoxide (Librium) and Oxazepam (Serax) have a lower likelihood of dependence, while Clonazepam (Klonopin) falls somewhere in between. However, Alprazolam (Xanax) is still widely prescribed for anxiety because it has a relatively quick onset of action and can be effective for short-term relief of symptoms. It is important for prescribers to monitor patients carefully and gradually taper the medication if it needs to be discontinued.

In Choosing a Benzodiazepam to Treat Anxiety the Prescriber Needs