Drugs are metabolized mainly by the liver via Phase I or Phase II reactions.The purpose of both of these types of reactions is to:

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Phase I and Phase II reactions both aim to modify the drug molecules to form a more polar, water-soluble compound that can be excreted by the kidneys. Phase I reactions usually involve oxidation or reduction, while Phase II reactions involve conjugation with other molecules such as glucuronic acid or amino acids. These modifications make the drug more easily excreted by the kidneys or liver.

Drugs Are Metabolized Mainly by the Liver Via Phase I