A significant loss of dopamine from the substantia nigra is specifically responsible for:

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The loss of dopamine from the substantia nigra is specifically responsible for problems initiating movement. This is because dopamine is necessary for normal functioning of the basal ganglia, which is responsible for initiating and controlling movement. A significant loss of dopamine is a hallmark feature of Parkinson's disease, which is characterized by motor impairment and difficulty initiating movement. A and D are incorrect choices as they both mention maintaining mental set, which is not directly related to dopamine loss from the substantia nigra. Choice C mentions maintaining balance, which is related to dopamine loss in the cerebellum, not the substantia nigra.

A Significant Loss of Dopamine from the Substantia Nigra Is