The hypothesis of hemiparkinsonism is based on the theory that:

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Hemiparkinsonism is characterized by parkinsonian symptoms that are limited to one side of the body. The theory behind this condition is that there is a disconnection between the basal ganglia and the cortex due to unilateral damage to the basal-cortical pathway. This disconnection results in an imbalance in dopamine signaling, leading to the onset of symptoms such as tremors, rigidity and bradykinesia.

The Hypothesis of Hemiparkinsonism Is Based on the Theory That