A prenatal anatomic disorder involving the failure of the two hemispheres of the brain to develop is termed:

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Holoprosencephaly is a developmental disorder in which the two hemispheres of the brain fail to separate during fetal development, resulting in a single-lobed brain structure. This can cause severe neurological and physical disabilities. Spina bifida is a disorder involving incomplete closure of the spinal cord, porencephaly is a disorder characterized by cysts or cavities in the brain, and focal dysplasia is a disorder involving abnormal growth or organization of cells in a specific area of the brain.

A Prenatal Anatomic Disorder Involving the Failure of the Two