Which event must take place for a B cell to become an antibody-secreting plasma cell?

Question

Quizplus · Accepted Answer

The binding of a T_H cell to an antigen‒MHC class II complex presented by the B cell is necessary for activation and differentiation of a B cell into an antibody-secreting plasma cell. This interaction provides the necessary co-stimulation for B cell proliferation and differentiation into plasma cells. Activation of the complement system, clonal deletion of nonreactive B cells, inflammation, and T_C cell activation may contribute to the overall immune response, but are not specifically required for B cell differentiation into plasma cells.

Which Event Must Take Place for a B Cell to Become