In cases of type II diabetes mellitus,continuous high concentrations of insulin have resulted in
A) the excretion of insulin.
B) increased insulin breakdown.
C) decreased insulin binding by target cells.
D) increased insulin binding by cells.
E) decreased synthesis of insulin.

Question

Quizplus · Accepted Answer

In cases of type II diabetes mellitus, there is typically a decreased sensitivity of target cells to insulin, which is known as insulin resistance. This means that the cells are unable to bind to insulin effectively, which decreases its ability to stimulate glucose uptake from the blood. As a result, the pancreas may produce more insulin to compensate for this resistance, but this can ultimately lead to a continuous high concentration of insulin in the blood. This can further contribute to insulin resistance by reducing the ability of cells to bind to insulin, as suggested by choice C.

In Cases of Type II Diabetes Mellitus,continuous High Concentrations of Insulin