Which event is the earliest to occur in puberty?
A) The hypothalamus releases increased levels of GnRH.
B) The level of circulating androgens rises in males.
C) The menstrual cycle is initiated in females.
D) The gonads differentiate into testes or ovaries.
E) The hypothalamic GnRH-producing cells become more sensitive to negative feedback from sex steroids and gonadotropins.
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