Use the Following to Answer Questions

Use the following to answer questions :
The hypothetical anti-anxiety drug Epitome is inactive when taken,but it is activated by the rasputin enzyme a few hours after injection.Alleles 1 and 2 of the gene that encodes rasputin have similar activity levels.Individuals with one or both copies of allele 3,which is very rare,have much higher levels of enzyme activity.Individuals who have both copies of allele 4 have much lower levels of enzyme activity.Heterozygotes of allele 4 have normal levels of enzyme activity.
-The individuals who are most likely to experience negative side effects from Epitome are those whose genotype has one copy of allele _______ and one copy of allele _______.

A) 1;2
B) 2;3
C) 2;4
D) 2;2
E) 4;4