Mutational "hot spots" often occur when a methyl group has been added to
A) adenine.
B) cytosine.
C) guanine.
D) thymine.
E) uracil.

Question

Quizplus · Accepted Answer

The addition of a methyl group to cytosine can lead to a mutational hot spot due to the conversion of cytosine to thymine through a process called deamination. Thymine is then recognized as a normal base and is not repaired, leading to a higher likelihood of mutations in that region. This phenomenon is often observed in CpG islands, which are regions in DNA where a cytosine is followed by a guanine.

Mutational "Hot Spots" Often Occur When a Methyl Group Has