Repair of an apurinic or apyrimidinic site in DNA by AP endonuclease must be completed by the action of

Question

Quizplus · Accepted Answer

AP endonuclease cleaves the phosphodiester bond at the apurinic or apyrimidinic site, creating a gap in the DNA strand. DNA polymerase I can then fill in the gap with the correct nucleotides and seal the nick with its 5' to 3' exonuclease activity. UvrABC endonuclease and RecA protein are involved in nucleotide excision repair and homologous recombination, respectively, and do not play a role in repairing AP sites.

Repair of an Apurinic or Apyrimidinic Site in DNA by AP