The major difference between the vacuoles of eukaryotes and the inclusion bodies of prokaryotes is that the former are membrane-bound whereas the latter are not.
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The statement is correct. Vacuoles in eukaryotic cells are membrane-bound structures that store various substances, while inclusion bodies in prokaryotes are aggregates of proteins, lipids, and other molecules that are not surrounded by a membrane.

The Major Difference Between the Vacuoles of Eukaryotes and the Inclusion