The concept of a prokaryote was first fully outlined in 1962 by

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Stanier and Van Niel fully outlined the concept of a prokaryote in 1962 through their publication "The Concept of a Bacterium." While Watson and Crick's discovery of the structure of DNA was groundbreaking, it did not directly relate to the definition of a prokaryote. Hersey and Chase's experiments confirmed that DNA was the genetic material, but again did not have a direct connection to the definition of a prokaryote. Gilbert and Cech were instrumental in the discovery of introns and RNA splicing, but this also did not directly relate to the definition of a prokaryote.

The Concept of a Prokaryote Was First Fully Outlined in 1962